The CXCL10/CXCR3 Pathway Contributes to the Synergy of Thermal Ablation and PD-1 Blockade Therapy against Tumors.

Compared with wild-type mice, the proportion of =CD8 + T cells in the control and anti-PD-1 treatment groups of Cxcl10 −/− mice was noticeably reduced, and the proportions of CD4 + T cells and Treg cells had a decreasing trend ( Figure 6 C).

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The multi-color flow cytometry analysis found that anti-PD-1 treatment increased the ratio of infiltrating CD45 + immune cells and CD8 + T cells in tumors compared with controls from wild-type mice, and there was an increasing trend in the proportion of CD4 + T cells and Treg cells ( Figure 6 C).

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