Some studies showed significant differences ( P = 0.09,[ 66 ] P = 0.063,[ 146 ] P = 0.054,[ 31 ] which were only marginally significant, P = 0.000,[ 71 ] P = 0.000,[ 144 ] P = 0.003,[ 65 ] P = 0.000,[ 4 ] P = 0.000[ 70 ]) and some did not demonstrate significant or marginally significant differences ( P > 0.1).[ 66 , 148 , 149 , 150 , 176 ] TREATMENT OF CONGENITALLY MISSING TEETH CMT has direct clinical implications.
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VAS and DHS L4-L5 MRI findings were evaluated according to physical activity level, and a moderately significant result was determined only for sedentary individuals ( r = 0.45, p = 0.00).
The most significant positive association was found between FEC and IgA measured in the nasal secretions of young ewes using both antigens (Rho = 0.5; p = 0.00); the correlation of FEC with IgA in serum was moderately significant (Rho = 0.306; p = 0.00).
In addition, difference in mean follow-up period between two groups was quite significant (87.1 months versus 65.9 months, p = 0.000) so that it could possibly give rise to another source of bias in aneurysm regrowth.
After controlling for the two factors of bone grafting and RBH, partial correlation analysis showed a moderately significant correlation between the ESBG and IPL, with a partial correlation coefficient of 0.560 (P=0.000).
Specifically, the calculation results of the meta-analysis revealed a moderately significant relationship between motivation and loyalty (r = 0.420, 95%CI = [0.321–0.505], p<0.000) with 16 observations.
A moderately significant relationship existed between the PCL-5 total score and pessimism schema (r = 0.463, p = 0.000) ( Table 2 ).
There was even a moderately significant correlation between parental economic distress and the BAS ( r = .44, P = .00).
The two partial correlations were both quite significant ( f versus txn rate/tlns per mRNA | protein production rate, complex membership: Spearman partial r = 0.227, n = 4,746, p = 10 −57 ; complex membership versus txn rate/tlns per mRNA | protein production rate, f: Spearman partial r = 0.147, n = 4,746, p = 10 −24 ), suggesting that fitness effect and protein complex membership are independently associated with the expression strategy that minimizes stochastic fluctuation.
The above nearly significant interaction, when comparing the 50 vs. 100% treatments, is marginal in comparison to the differences in density across weeks ( z = −16.916, p < 2e-16).
Association testing on all HLA alleles in a combined group of persistent and extended oligoarthritis JIA ILAR subtypes revealed that position 11 of HLA‐DRB1 was again the strongest signal, but with a more modest significance ( P = 5.1 × 10 −14 ).
In the case of the topoisomerase II inhibitors, 12% of the etoposide-associated CNVs were found to associate with daunorubicin IC 50 , and the observed overlap is still quite significant ( P = 2.7 × 10 -10 ).
For example, of the 559 genes in the Chen androgen signature (448 of which were represented in at least three prostate tumor datasets), 29 were correlated ( p <0.05) with KLK3 in at least three out of the four prostate tumor datasets; by chance, nine were expected, and so the amount of actual overlap was quite significant ( p = 1.2E-08).
The results show that TPSA is quite significant ( p -value = 4.1 × 10 − 8 ).
We obtained completely significant cis-eQTL (FDR < 0.05) and cis-pQTL ( p < 5e-08), as well as allele frequency information, as shown in (Supplementary Table 1).
We run a GWAS Cox model, with the first 10 PCs, age, age 2 , sex, period of infection and patient series as covariates and we found one variant (rs117011822) associated with survival at P -value < 5.0 × 10 −8 (genome-wide significance level) and another one (rs7208524) nearly significant ( P -value = 5.19 × 10 −8 ).
Interestingly, the OS genome-wide analysis identified 10 nearly significant variants (p value=6.3× 10 −8 ) on chromosome 2, in complete LD with each other ( figure 2 ).
Auditory spectrotemporal receptive fields (STRFs) (Figure 9C,Di ) were only moderately affected in Otogl +/− mutant mice relative to Otogl +/+ controls, with a slightly significant change in response latency ( p = 7.10 −8 , nested two‐way ANOVA, group effect, animal factor nested in group, F(1,1379) = 29.5) and a 5.8% decrease in frequency bandwidth ( p = 0.048, nested ANOVA, F(1,1379) = 3.9), with no change in maximum evoked firing rate ( p = 0.06, nested ANOVA, F(1,1379) = 3.5).
Results Among pediatric subjects with WGS data, we identified a significant intronic variant in EDIL3 (rs149378, P = 1.9 × 10 −8 ) and a nearly significant intronic variant in LHX4 (rs79008224, P = 7.2 × 10 −8 ).
In addition, a large 1.4 Mb region at chromosome 17q21.31, coextensive with a known inversion polymorphism, 42 harbored 101 nearly significant SNPs (all P 's<10 −6 ; top SNP, rs916888, P =8.18 × 10 −8 ).
Two imputed SNPs (rs115231074: p = 1.3 x 10 −10 and rs35079132: p = 3.8 x 10 −8 ) achieved genome-wide significance, and one adjacent genotyped SNP was nearly significant genome-wide (rs4321864: p = 8.8 x 10 −8 ).
For example, there were significant associations between PTVs in PSAP and increased progranulin ( GRN ; P = 5.5 × 10 −17 ; β = 2.60; 95% CI, 1.99 to 3.21) and cathepsin B ( P = 1.2 × 10 −11 ; β = 2.10; 95% CI, 1.49 to 2.70), and a nearly significant association with increased cathepsin D ( P = 9.0 × 10 −8 ; β = 1.61; 95% CI, 1.02 to 2.20) (Supplementary Table 8 ).
Statistical power drops off rapidly as the interaction odds ratio goes from 1.50–1.25; even at a modest significance level of P < 10 −7 , we did not have power to detect an interaction with an odds ratio of 1.25 for any condition ( Table S7 ).
For AMD, we identified one genome-wide significant locus in 18q22.2, rs12956753 (OR = 1.71, p = 3.76 × 10 −8 ), and another nearly significant locus in 15q14, rs138597498 (OR = 1.75, p = 1.02 × 10 −7 ), located near the genes DOK6 and DPH6 , respectively ( Figure 1 B).
27 Although the published FSHB promoter polymorphism was not the strongest signal in this region, it was genome-wide significant for association with LH in our data ( P= 4.84 × 10 −9 ), and nearly significant for FSH ( P= 2.31 × 10 −7 ) ( Supplementary Table 11 ).