Enhanced Apoptosis and Loss of Cell Viability in Melanoma Cells by Combined Inhibition of ERK and Mcl-1 Is Related to Loss of Mitochondrial Membrane Potential, Caspase Activation and Upregulation of Proapoptotic Bcl-2 Proteins.

Int J Mol Sci · 2023 · PMC10002974 · PMID 36902392

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hedged sentence

0.0100

closest p · 0.2× alpha

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boldest claim

The sentences

highly significantp < 0.01actually significant

The increase in both cell death fractions by combination treatment was highly significant, as compared to the single treatments as well as compared to control cells ( p < 0.01; Figure 4 ).

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