Skeletal Muscle-Derived Exosomal miR-146a-5p Inhibits Adipogenesis by Mediating Muscle-Fat Axis and Targeting GDF5-PPARγ Signaling.

After aKO mice were injected with Flox-Exos, IngWAT and EpiWAT tissue weight in mice was significantly reduced ( Figure 7 h), and the fat mass in body composition decreased significantly, while the lean content showed an increasing trend ( Figure 7 i), and in vivo imaging also showed fat enrichment was decreased compared to injected with mKO-Exos ( Figure 7 j).

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