Secretogranin II influences the assembly and function of MHC class I in melanoma.

Exp Hematol Oncol · 2023 · PMC10007832 · PMID 36906639

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highly significantno p-value reported

Hereafter, we analyzed the expression of SCG2 and the HLA genes, which encode the heavy chain of the MHC-I complex, in melanoma patients (n = 87) from a GSE database ( GSE7553 ) and found a highly significant negative correlation between SCG2 and HLA-A, HLA-B and HLA-C expression (Fig. 1 I).

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