Intriguingly, a specific clone of CAFs associated with ECM (eCAFs) is identified in pancreatic cancer [ 339 ] and gastric cancer [ 340 ], and recently identified Endo180 and paired related homeobox 1 (Prrx1) may be significant genes associated with the function and plasticity of eCAFs [ 341 , 342 ].
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Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments.
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