Single-cell and spatial dissection of precancerous lesions underlying the initiation process of oral squamous cell carcinoma.

Cell Discov · 2023 · PMC10011538 · PMID 36914617

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an increasing trendno p-value reported

Moreover, spatial-switching of VEGF signaling was observed from the upper layer of epithelium in N and DN stages to basal layers and tumor regions of epithelium in DN and T stages, with an increasing trend in communications with the surrounding ecosystem.

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