Tongmai Yangxin pill alleviates myocardial no-reflow by activating GPER to regulate HIF-1α signaling and downstream potassium channels.

Effect of TMYX on the expression of the GPER, ERK, HIF-1α gene, and protein in the myocardium of NR rats The expression of GPER, ERK, HIF-1α , GPER, and HIF-1α proteins was significantly decreased in the NR group ( p < 0.05, p < 0.01 and p < 0.001), and the expression of the p-ERK protein in the NR group showed a decreasing trend, compared with that in the Sham group ( Figure 5(A–C) ).

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TMYX treatment increased the expression levels of GPER, HIF-1α gene, and protein ( p < 0.05, p < 0.01), while the expression of ERK and p-ERK proteins in the TMYX group showed an increasing trend, compared with that in the NR group.

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