highly significantp < 0.001
Comparison of the tnpMPI in cohorts 1, 2 and 3, visited consecutively, resulted in a highly significant minimum median tnpMPI of 10.0 min (IQR 4.3) for cohort 3, decreasing from 15.5 min (median, IQR 5.3) to 15.0 min (median, IQR 7.0) for cohorts 1 and 2 ( p < 0.001 each, post hoc test, Fig. 2 ).