Hydrophobic Ion Pairing of Small Molecules: How to Minimize Premature Drug Release from SEDDS and Reach the Absorption Membrane in Intact Form.

Statistical data analyses were performed using Student’s t -test with p < 0.05 for significant (*), p < 0.01 for very significant (**), and p < 0.001 for highly significant (***). 3 Results and Discussion 3.1 Hydrophobic Ion Pairing of Ethacridine To increase the lipophilicity of ethacridine via hydrophobic ion pairing, various counterions classified by functional groups of phosphates, sulfates, and sulfonates, were screened.

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