Longitudinal multi-omics alterations response to 8-week risperidone monotherapy: Evidence linking cortical thickness, transcriptomics and epigenetics.

Front Psychiatry · 2023 · PMC10018025 · PMID 36937723

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0892

boldest claim

The sentences

marginal significanceP = 0.060so close (0.05 < p ≤ 0.1)

Patients had significant clinical improvement in positive and general psychopathology symptoms ( Ps < 0.001; Supplementary Table S2 ), while their alterations in negative symptom dimension showed marginal significance ( P = 0.060; Supplementary Table S2 ).

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marginally significantP = 0.0892so close (0.05 < p ≤ 0.1)

Between-group comparisons of CT Compared with healthy volunteers, patients_0W had significant increases of CT in the R_pericalcarine ( Supplementary Table S3 , P = 0.006, FDR corrected), while marginally significant increases in the L_entorhinal, R_entorhinal, and L_pericalcarine cortices ( Supplementary Table S3 , P = 0.0892, 0.0763, and 0.0794 respectively, FDR corrected).

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