Valproate-related neutropenia and lithium-related leukocytosis in patients treated with clozapine: a retrospective cohort study.

Moreover, a decreasing trend of leukocytosis development was observed with increasing age ( p < .001; Fig. 1 B).

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Regarding lithium dosage, with a dosage of < 600 mg as the reference group, each of the other two subgroups (i.e., 601–1200 mg and > 1200 mg) demonstrated no significant difference in leukocytosis development; however, an increasing trend of leukocytosis incidence with an increase in lithium daily dosage was observed ( p < .001; Fig. 1 D).

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