An image-based high-content screening for compounds targeting <i>Toxoplasma gondii</i> repurposed inhibitors effective against the malaria parasite <i>Plasmodium falciparum</i>.

Dose-dependent inhibitory effects of the small molecules on T gondii growth The inhibitory activity of the compounds identified through image-based screening was validated by another enzymatic method and the findings revealed a highly significant difference (p < 0.0001) in parasite growth depending on the inhibitor presence and concentration used, reflecting an important effect of inhibitors on the intracellular replication of T. gondii using β-galactosidase assays ( Figures 9A, B ).

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