Degradation of collagen I by activated C1s in periodontal Ehlers-Danlos Syndrome.

Front Immunol · 2023 · PMC10028100 · PMID 36960056

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highly significantno p-value reported

Our previous studies identified extracellular presence of activated C1s (aC1s) as the common pathological feature in pEDS patient fibroblast cultures, and showed highly significant activation of complement 4 (C4) after its addition to pEDS but not control fibroblast supernatant in vitro ( 10 ).

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