After tumor stratification by disease stage, miR‐10400‐5p and miR‐30d‐5p, resulted up‐regulated compared to healthy controls, in both stage I–II (log 2 FC = 1.93 and log 2 FC = 3.13, respectively) and stage III–IV (log 2 FC = 2.62; log 2 FC = 5.23) with an increasing trend. miR‐6849 was down‐regulated in CRC stage I–II (log 2 FC = −1.44) and stage III–IV (log 2 FC = −1.04) when compared to healthy controls. miR‐151a‐3p (log2FC = 2.08) and miR‐1302 (log2FC = −0.97) were, respectively, up‐ and down‐regulated only in stage III‐IV (Table S7B ).
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The 8q24 region hosts miRNAs altered in biospecimens of colorectal and bladder cancer patients.
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Specifically, miR‐30d‐5p also showed a decreasing trend of expression going from normal tissues to stage III‐IV tumors; conversely, miR‐937‐3p and miR‐939‐5p showed an increasing expression trend (Table S1B ).