Spontaneous neurotransmission at evocable synapses predicts their responsiveness to action potentials.

Importantly, the effect of the number of spontaneous events was also strongly statistically significant ( p < 0.0001) with a positive trend ( p = 0.045) in separate experiments in which we first measured AP-evoked activity and afterward measured spontaneous activity (inverse sequence; Supplementary Figures 4A, B ), ruling out effects of e.g., activity run-down and fluorescence bleaching.

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