Adamantanes for the treatment of neurodegenerative diseases in the presence of SARS-CoV-2.

Front Neurosci · 2023 · PMC10031118 · PMID 36968489

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On the other hand, results of a systematic review with meta-analysis of the results of 30 RCTs involving 7,567 patients demonstrated that the adamantane analog, memantine ( Figure 1 ) was effective for the improvement of cognitive function in patients with AD compared to placebo, a finding that was highly significant either with or without the addition of cholinesterase inhibitors ( Kishi et al., 2017 ).

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