Granulin loss of function in human mature brain organoids implicates astrocytes in TDP-43 pathology.

Thus, to determine if CrSTMN2 transcripts can be detected in our model system showing TDP-43 mis-localization, we adapted a method ( Klim et al., 2019 ) to develop a sensitive quantitative PCR (qPCR)-based assay and found a highly significant, approximately 4-fold increase in CrSTMN2 in the GRN −/− versus GRN +/+ mbOrgs ( Figure 1 G).

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