GlyPerA™ effectively shields airway epithelia from SARS-CoV-2 infection and inflammatory events.

Upon quantifying C3 signals from more than 1000 cells/condition in UI, Omicron- and GlyPerA/Omicron-exposed, pseudostratified respiratory epithelia, we found highly significant differences in percentages of C3 + areas (Fig. 2 c) These analyses demonstrate that infection going along with tissue destruction and intracellular C3 mobilization on 3 dpi induced in NHBE cultures upon SARS-CoV-2 interactions can be avoided by pre-treatment with or simultaneous addition of GlyPerATM solution to epithelia.

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