SLiM CRAB criteria revisited: temporal trends in prognosis of patients with smoldering multiple myeloma who meet the definition of 'biomarker-defined early multiple myeloma'-a systematic review with meta-analysis.

EClinicalMedicine · 2023 · PMC10033724 · PMID 36969337

Europe PMC DOI

hedged sentences

0.0001

closest p · 0.0× alpha

0.0421

boldest claim

The sentences

highly significantp < 0.0001actually significant

The OR for the 2-year risk of progression between patients with >1 and those with ≤1 MRI-defined focal lesions was also highly significant (OR: 10.53, 95% CI 4.96–22.37, p < 0.0001) for the early data.

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borderline significantp = 0.0421actually significant

The TTP of patients with ≥60% BMPCs reported in the early studies was significantly shorter than the one for data published in later years (HR: 0.27, 95% CI 0.14–0.51, logrank p < 0.0001); in contrast, a borderline significant weak trend in the opposite direction was recorded in patients with <60% BMPCs (HR: 1.22, 95% CI 1.01–1.47, logrank p = 0.0421).

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