Molecular characterization of extracellular vesicles derived from follicular fluid of women with and without PCOS: integrating analysis of differential miRNAs and proteins reveals vital molecules involving in PCOS.

Next, in order to further explore the physiological roles and regulatory mechanisms of DEmiRNAs in FF-EVs possibly involved in PCOS, 514 DEmiRNAs were narrowed down according to the highly significant p value. 6 DEmiRNAs, e.g., hsa-miR-3131(up), hsa-miR-206 (up), hsa-miR-204-5p (up), hsa-miR-100-5p (up), hsa-miR-193a-5p (up), and hsa-miR-539-5p (down), were picked out for further predicting their target genes.

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