Crosstalk between protein kinase C α and transforming growth factor β signaling mediated by Runx2 in intestinal epithelial cells.

There is a highly significant correlation ( p < 0.001) between PKCα and TGFβR1 mRNA expression levels in human colon tumor samples, implying co-occurrence of loss of expression of the two kinases in tumors ( Fig. 11 A i).

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