Trends of Cirrhosis-related Mortality in the USA during the COVID-19 Pandemic.

Overall analysis of all-cause cirrhosis-related mortality Before the pandemic, prior to 4/2020, there was a slightly increasing trend in cirrhosis-related mortality per 100,000 persons overall at a semiannual percentage change (SAPC) of 0.54% (95% CI 0.0–1.0%, p =0.036), with seasonal variation ( Fig. 1A, B and Table 2 ).

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Following an increasing trend of cirrhosis-related mortality before the pandemic, with a semiannual percentage change (SAPC) of 0.54% [95% confidence interval (CI): (0.0–1.0%), p =0.036], a precipitous increase with seasonal variation occurred during the pandemic (SAPC 5.35, 95% CI: 1.9–8.9, p =0.005).

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