Mediation effects of DNA methylation and hydroxymethylation on birth outcomes after prenatal per- and polyfluoroalkyl substances (PFAS) exposure in the Michigan mother-infant Pairs cohort.

Clin Epigenetics · 2023 · PMC10037903 · PMID 36964604

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suggestive of significancep < 0.1so close (0.05 < p ≤ 0.1)

PFAS and birth outcomes: mediation by epigenetics Across all families with passing total DNA methylation data ( n = 141), there were several relationships suggestive of significance ( p < 0.1) between birth outcomes (gestational age at birth, or Fenton z-scores) and PFAS exposures, when controlling for the necessary confounders for statistical mediation analyses (Table 6 ).

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