Alterations in oligodendrocyte transcriptional networks reveal region-specific vulnerabilities to neurological disease.

M4, which is upregulated in cortical OLs, is enriched for the GO term synaptic transmission and has highly significant enrichment for epilepsy- (2.8-fold enriched, FDR = 2.3 × 10 −8 ) and ID-associated genes (2-fold enriched, FDR = 7.7 × 10 −8 ) ( Figure 3 ).

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