Increased hepatic interleukin-1, arachidonic acid, and reactive oxygen species mediate the protective potential of peptides shared by gut cysteine peptidases against Schistosoma mansoni infection in mice.

Principal findings Immunization of outbred mice with MAP-2 in combination with alum and/or MAP-1 elicited highly significant ( P < 0.005) reduction of around 60% in challenge S . mansoni worm burden and no increase in worm eggs’ loads or vitality, compared to unimmunized or alum pre-treated control mice.

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