FBXW7 attenuates tumor drug resistance and enhances the efficacy of immunotherapy.

Front Oncol · 2023 · PMC10043335 · PMID 36998461

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extremely significantno p-value reported

A positive feedback loop consisting of NICD/Hes5/FBXW7 was identified in colon cancer cells, where the negative regulation of FBXW7 by Hes5, particularly its repressive effect on the transcription of FBXW7, is extremely significant ( 47 ).

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