GOCC analysis of our data sets showed a highly significant enrichment for the term nucleus for PDE3 (for the PDE3A1 interactome: 107/6630 genes and FDR, 9.91×10 −43 ; for the PDE3A2 interactome: 68/6630 genes and FDR, 7.32×10 −6 ; for the PDE3 phosphoproteome: 107/6630 genes and FDR, 4.4×10 −10 ; Appendix S3 ).
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Integrated Proteomics Unveils Nuclear PDE3A2 as a Regulator of Cardiac Myocyte Hypertrophy.
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