Inhibition of Microglial Activation by Amitriptyline and Doxepin in Interferon-β Pre-Treated Astrocyte-Microglia Co-Culture Model of Inflammation.

Treatment with amitriptyline, doxepin or IFN-β alone led to a highly significant increase in the resting ramified type of microglia (RRT) ( Figure 4 A) with a parallel, significant decrease in the activated phenotype (RPT) ( Figure 4 B) compared to the control under pathological, inflammatory M30 conditions ( p ≤ 0.0001: ****) ( n = 27).

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