Stromal Senescence following Treatment with the CDK4/6 Inhibitor Palbociclib Alters the Lung Metastatic Niche and Increases Metastasis of Drug-Resistant Mammary Cancer Cells.

Most of the highly significant gene changes seen at 10 days in both groups did not persist after 14 days of holiday from palbociclib or after 14 days of continued AP after palbociclib + AP treatment, though many genes were dysregulated in the Residual Effect cohort with large-magnitude fold-change values, albeit to lesser degrees of statistical significance ( Figure 2 B).

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