Prognostic Role of Soluble and Extracellular Vesicle-Associated PD-L1, B7-H3 and B7-H4 in Non-Small Cell Lung Cancer Patients Treated with Immune Checkpoint Inhibitors.

In particular, while an increasing trend in PD-L1+ EVs was found to be associated with a higher non-response rate (RR = 5.67; 95% CL = 1.80 − 17.9), a similar but inverse effect was observed in B7-H3+ EVs, which showed a reduction of about 70% (RR = 0.29; 95% CL = 0.11 − 0.81) ( Table S8 ). 3.5.

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