Barely Significant
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Amantadine Toxicity in <i>Apostichopus japonicus</i> Revealed by Proteomics.

Toxics · 2023 · PMC10053536 · PMID 36976991

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a decreasing trendno p-value reported
The SOD enzyme activities in the experimental group were always lower than those of the control group at each time point, but showed an overall increasing and then a decreasing trend.

also in 20,123 other papers

an overall trendno p-value reported
However, there was an overall trend of decreasing and then increasing.

also in 1,651 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.