The melatonin receptor 1B gene links circadian rhythms and type 2 diabetes mellitus: an evolutionary story.

The nadir of human endogenous cortisol occurs at midnight, and the levels rise for 2-3 h after sleep onset, followed an increasing trend until 9 o’clock in the morning (the peak); a lower level is then maintained during the day, with a decline usually during the later afternoon [ 90 ].

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