Mutagenic analysis of actin reveals the mechanism of His161 flipping that triggers ATP hydrolysis.

Front Cell Dev Biol · 2023 · PMC10062479 · PMID 37009486

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a slight trendno p-value reported

The GF-axis values were maintained at ∼11° for both WT and A108G regardless of the protonation state of His161, indicating that the F-form was maintained during the MD simulation, although there was a slight trend from the F-form to the G-form transition ( Figures 5A–C ).

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