In contrast, although a slight trend may have been apparent, we did not find a significant difference between stimulus flicker frequencies for the global cortical BOLD signal, suggesting that brain-wide hemodynamic effects were similar despite focal differences in visual cortex ( Fig 3C , 95% CI for the difference in the AUC of cortex between each frequency and 4 Hz: [−1.35, 1.65], [−0.51, 2.12], [−0.02, 1.55], Bonferroni corrected ) .
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Neural activity induced by sensory stimulation can drive large-scale cerebrospinal fluid flow during wakefulness in humans.
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