A snapshot on HIV-1 evolution through the identification of phylogenetic-specific properties of HIV-1 integrases M/O.

PLoS Pathog · 2023 · PMC10062586 · PMID 36996029

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an overall trendno p-value reported

The emergence of the CLA motif, instead, appears to date after transmission of the virus to the human host, since no conservation is found in this region in SIVcpz Ptt , although an overall trend for the presence of amidic and basic residues (as those composing the consensus sequence of the motif in HIV-1 M) is found.

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