Barely Significant
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Locked-in syndrome revisited.

Ther Adv Neurol Disord · 2023 · PMC10064471 · PMID 37006459

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a positive trendno p-value reported
165 Although a systematic review found insufficient evidence for the benefits of physical exercise in physical recovery of LiS patients, a positive trend was seen for muscle strength, tone, walking ability and activities in daily living and the need for well-designed studies was stated. 166 As in stroke patients, repetitive sensorimotor training could be beneficial for LiS patients. 167 Sildenafil citrate is hypothesized to support recovery. 168 To raise the chances for a LiS patient to return home, the involvement of relatives in rehabilitation should be considered. 24 Furthermore, psychological and psychiatric support and treatment is essential.

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