highly significantp < 0.001
The diabetic groups treated either with insulin or REO showed a highly significant decrease in the level of serum urea (insulin: 37.32± 10.05 mg/dl, REO: 3.1± 1.03 mg/dl, p < 0.001) and a significant decrease in the level of uric acid (insulin: 3.1± 1.23 mg/dl, REO: 4.03± 1.76 mg/dl, p < 0.05) when compared with the diabetic untreated group.