A study on the prevention of hemorrhage and perforation in patients with primary gastric diffuse large-B cell lymphoma during treatment with immunochemotherapy.

The estimated relative risks associated with the use of glucocorticoids alone to treat gastrointestinal adverse effects vary from 1.1 (not significant) to 1.5 (marginally significant). 11 , 15 In addition to upper gastrointestinal morbidity, visceral perforation is another complication associated with glucocorticoid use. 7 , 16 , 17 To our knowledge, the R‐CHOP regimen contains a high dose of prednisone, so the patients in the prevention group received standard R‐CHOP treatment without prednisone until the complete recovery of gastric ulcers.

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