Prediction of Crohn's Disease Stricturing Phenotype Using a NOD2-derived Genomic Biomarker.

Kugathasan and colleagues previously detailed a joint model for stricturing and penetrating complications, performing with borderline significance (specificity 63%, sensitivity 66%). 7 Interestingly, an NOD2 genotype (analysis of the 3 common variants only—rs2066844, rs2066845, and rs2066847) was not a significant predictor in the competing-risk model, whereas CBir1 seropositivity and an extracellular matrix gene expression signature were positively associated with a B2 disease phenotype.

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We were able to stratify patients into highly significant high- and low-risk groups for development of stricturing disease.

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