MLKL deficiency protects against low-grade, sterile inflammation in aged mice.

It was noted, however, that 9-month-old female Mlkl –/– mice exhibited an increasing trend in the total number of inflammatory foci in areas of skeletal muscle, bone, cartilage, adipose tissue, and connective tissue proper compared to wild-type littermate controls (Fig. 5C , Supplementary Fig. 5B ).

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