Effects of 1-methyl-1, 2, 3, 4-tetrahydroisoquinoline on a diabetic neuropathic pain model.

In animals subjected to the streptozotocin protocol (STZ-DPN), there was a highly significant ( p < 0.0001) reduction (95%) in PWT (>0.12 g i.e., static mechanical allodynia) which was restored to a level that was comparable to the saline-treated group (>2.5 g) by the dose of gabapentin (75 mg/kg) as the positive control standard drug ( Figures 1A–C ).

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