Differential splicing of neuronal genes in a Trem2*R47H mouse model mimics alterations associated with Alzheimer's disease.

BMC Genomics · 2023 · PMC10074678 · PMID 37016304

Europe PMC DOI

hedged sentence

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp = 2.78 × 10 –6actually significant

Notably, 8 of these 12 genes ( ENO2, LUC7I3, KIF21A, MAP4K4 , PPP3CA, MACF1, NDRG4, and PRRC2C ) were differentially spliced in 12-month-old Trem2*R47H mice, which was highly significant (hypergeometric p = 2.78 × 10 –6 ) (Table 3 ).

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