At the same time, a large data set of mRNA bulk data from the Lung Tissue Research Consortium (Gene Expression Omnibus database accession number GSE47460 ) ( 24 ) did not present significant differences in the expression of NAD + -consuming enzymes ( Supplemental Figure 1B ) but a highly significant decrease in CYB5R3 expression in IPF when compared with healthy lungs ( Supplemental Figure 1C ).
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CYB5R3 in type II alveolar epithelial cells protects against lung fibrosis by suppressing TGF-β1 signaling.
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