Premature Progesterone Elevation in <i>in vitro</i> Fertilisation Cycles - Current Perspectives.

The recent meta-analysis showed marginally significant evidence that GnRH antagonist protocol was associated with a decreased incidence of PPE irrespective of the threshold used compared to agonist cycles.[ 3 ] However, few other publications have found a similar incidence of PPE in both agonist and antagonist protocols.[ 18 , 19 ] Type of gonadotropin Before the routine use of GnRH analogues in IVF stimulation, premature luteinisation and elevated progesterone were common and were attributed to the excessive effect of LH on the growing follicles causing luteinisation and progesterone production.

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This study also observed a 37.8% decline between the first and last drawn sample and a highly significant decline in levels between 8 am and 11 am.[ 62 ] These studies highlight the diurnal variation of P on trigger day and the remarkable decline in levels observed during the day.

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