The comparison of average fold changes for “HERV-activating” samples (1.99 ± 0.7 for W- ENV and 1.95 ± 0.4 for K- ENV ) and “non HERV-activating” subgroup (0.74 ± 0.26 for W- ENV and 1.06 ± 0.23 for K- ENV ) showed consistently highly significant difference, (i) an increase in mRNA expression in virus-exposed versus mock-exposed cells for both W- ENV and K- ENV in the subgroup of HERV-activating donors and (ii) decrease in RNA expression in virus-exposed versus mock-exposed cells for W- ENV and K- ENV, in the subgroup of HERV-non-activating donors (p < 0.0001, F test).
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SARS-CoV-2 awakens ancient retroviral genes and the expression of proinflammatory HERV-W envelope protein in COVID-19 patients.
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