Epithelial Barrier Hypothesis and Its Comparison with the Hygiene Hypothesis.

Turk Arch Pediatr · 2023 · PMC10081018 · PMID 36856348

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an increasing trendno p-value reported

The frequency differed from 1.1% to 3.1% among the population born before 1960, 16 , 17 whereas an increasing trend was suggested by tabulating individual year groups after the 1960s, reaching 12% in 1974. 18 Hygiene Hypothesis In 1989, David Strachan came up with the idea of “hygiene hypothesis” to explain the increase in allergic disorders.

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