Barely Significant
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Tranexamic Acid in Melasma: Comparative Evaluation of Therapeutic Efficacy of Oral Tranexamic Acid versus Its Transepidermal Administration.

J Cutan Aesthet Surg · 2022 · PMC10081479 · PMID 37035597

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a decreasing trendno p-value reported
The MASI score showed a decreasing trend as the treatment continued.

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highly significantno p-value reported
When compared, highly significant improvement was obtained in both the groups, but there was no statistically significant difference between the two groups with regard to the overall response seen in the subjects.

also in 132,142 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.