Homologous recombination deficiency derived from whole-genome sequencing predicts platinum response in triple-negative breast cancers.

At the genomic level, the association of BRCA1/2 mutations with platinum response was close to significance.

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There is a decreasing trend in the proportion of RAD51 positive models in treated samples of the 3 response groups (Fig. 3d ) and a low RAD51 score was significantly associated with response, although it failed to predict stable disease that was associated with a high RAD51 score in 5/7 cases (Fig. 3e ).

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