While several highly significant positive correlations between complement and laboratory parameters can be observed in COVID-19 cases, none of the correlations observed in healthy controls passed correction for multiple testing. 3.4 Short or long haplotype combinations of MBL2 do not associate with COVID-19 Since activation of the lectin pathway is highly dependent on its key pattern recognition molecule MBL, genotyping of the MBL2 gene was performed for both COVID-19 cohorts as well as for the healthy controls.
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Complement lectin pathway activation is associated with COVID-19 disease severity, independent of <i>MBL2</i> genotype subgroups.
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